- Prispevkov: 21
- Pridružen: 25 Avg 2012, 00:58
Ali sem jaz študije prav raztolmačil da whey proteini povzročijo višji spike inzulina kot beli kruh? In, da določene kombinacije aminokislin povzročijo celo še višji spike oz. izločanje inzulina? Če to drži, potem David (glede na to kako pri hujšanju poudarja, da je potrebno jesti hrano z nizkih GI hkratno priporoča tudi whey proteini) lahko doda svojim člankom o inzulinu zanimivo novico
.
Celotna študija http://www.nutritionandmetabolism.com/c ... 5-9-48.pdf
POVZETEK ( http://www.ncbi.nlm.nih.gov/pubmed/22647249 ) - so notri še neke primerjave z določenimi AK in glukozo.
The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on beta-cells
Albert Salehi, Ulrika Gunnerud, Sarheed J Muhammed, Elin Östman, Jens J Holst, Inger Björck and Partik Rorsman
Background
Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). We have examined the effects of these putative mediators of whey's action on insulin secretion from isolated mouse Langerhans islets.
Methods
Mouse pancreatic islets were incubated with serum drawn from healthy individuals after ingestion of carbohydrate equivalent meals of whey protein (whey serum), or white wheat bread (control serum). In addition the effect of individual amino acid combinations on insulin secretion was also tested. Furthermore, the stimulatory effects of whey serum on insulin secretion was tested in vitro in the absence and presence of a GIP receptor antagonist ((Pro(3))GIP[mPEG]).
Results
Postprandial amino acids, glucose-dependent insulinotropic polypeptide (GIP) and glucagonlike peptide 1 (GLP-1) responses were higher after whey compared to white wheat bread. A stimulatory effect on insulin release from isolated islets was observed with serum after whey obtained at 15 min (+87%, P < 0.05) and 30 min (+139%, P < 0.05) postprandially, compared with control serum. The combination of isoleucine, leucine, valine, lysine and threonine exerted strong stimulatory effect on insulin secretion (+270%, P < 0.05), which was further augmented by GIP (+558% compared to that produced by glucose, P < 0.05). The stimulatory action of whey on insulin secretion was reduced by the GIP-receptor antagonist (Pro(3))GIP[mPEG]) at both 15 and 30 min (56% and 59%, P < 0.05).
Conclusions
Compared with white wheat bread meal, whey causes an increase of postprandial insulin, plasma amino acids, GIP and GLP-1 responses. The in vitro data suggest that whey protein exerts its insulinogenic effect by preferential elevation of the plasma concentrations of certain amino acids, GIP and GLP-1.
Celotna študija http://www.nutritionandmetabolism.com/c ... 5-9-48.pdf
POVZETEK ( http://www.ncbi.nlm.nih.gov/pubmed/22647249 ) - so notri še neke primerjave z določenimi AK in glukozo.
The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on beta-cells
Albert Salehi, Ulrika Gunnerud, Sarheed J Muhammed, Elin Östman, Jens J Holst, Inger Björck and Partik Rorsman
Background
Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insulinotropic polypeptide (GIP). We have examined the effects of these putative mediators of whey's action on insulin secretion from isolated mouse Langerhans islets.
Methods
Mouse pancreatic islets were incubated with serum drawn from healthy individuals after ingestion of carbohydrate equivalent meals of whey protein (whey serum), or white wheat bread (control serum). In addition the effect of individual amino acid combinations on insulin secretion was also tested. Furthermore, the stimulatory effects of whey serum on insulin secretion was tested in vitro in the absence and presence of a GIP receptor antagonist ((Pro(3))GIP[mPEG]).
Results
Postprandial amino acids, glucose-dependent insulinotropic polypeptide (GIP) and glucagonlike peptide 1 (GLP-1) responses were higher after whey compared to white wheat bread. A stimulatory effect on insulin release from isolated islets was observed with serum after whey obtained at 15 min (+87%, P < 0.05) and 30 min (+139%, P < 0.05) postprandially, compared with control serum. The combination of isoleucine, leucine, valine, lysine and threonine exerted strong stimulatory effect on insulin secretion (+270%, P < 0.05), which was further augmented by GIP (+558% compared to that produced by glucose, P < 0.05). The stimulatory action of whey on insulin secretion was reduced by the GIP-receptor antagonist (Pro(3))GIP[mPEG]) at both 15 and 30 min (56% and 59%, P < 0.05).
Conclusions
Compared with white wheat bread meal, whey causes an increase of postprandial insulin, plasma amino acids, GIP and GLP-1 responses. The in vitro data suggest that whey protein exerts its insulinogenic effect by preferential elevation of the plasma concentrations of certain amino acids, GIP and GLP-1.
